High‐dose antipsychotics were used in 2.5% of the monotherapy group and in 38% of the polypharmacy group. An ECG was done in 35% of patients on high‐dose antipsychotic therapy. In the monotherapy group, 6.2% versus 26.5% in the polypharmacy group of patients were on at least 1 sedative or hypnotic (odds ratio [OR], 5.47; 95% confidence interval [CI], 2.02–14.82; P < .001). Apr 21, 2020 · Antipsychotic medications are first-line medication treatment for schizophrenia. They have been shown in clinical trials to be effective in treating symptoms and behaviors associated with the disorder. Antipsychotic medications have significant side effects; assessment and management of these adverse effects are an important part of treatment.
Nov 07, 2008 · Much of the available literature on psychotropic polypharmacy has focused on antipsychotic polypharmacy. 8,9,11,12,17,21,26,40,41 Frequently, antipsychotic polypharmacy represents an attempt by the physician to achieve a greater or a faster therapeutic response. 11 Many patients in routine care settings continue to experience significant symptoms while following usual treatment regimens. 42 In other cases, antipsychotic polypharmacy may be the result of “getting stuck” in switching from ...

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Antipsychotic (AP) polypharmacy is common in psychiatric practice, despite concerns about its risks and questions regarding its effectiveness. 1-4 One concern when prescribing antipsychotic drugs ...
Antipsychotic polypharmacy has increased over the years, and current evidence suggeststhat it may have some clinical benefits, most likely by enabling individualized and tailored antipsychotic treatment regimens for better symptom con-trol [4, 5]. Consequently, combined treatment strategies are frequently applied for treatment-refractory symptoms, even

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Abstract Antipsychotic polypharmacy (APP) is a common strategy despite guidelines advising against this practice. This article seeks to quantify the prevalence and correlates of APP using Medicaid Analytic eXtract files from 2003 to 2004. Nineteen percent of Medicaid recipients who received an antipsychotic were treated with APP.
Jan 16, 2017 · The full guideline states that many types of psychotropic medicines have been used to manage behaviour that challenges, including antipsychotics, antidepressants, mood stabilisers and sedatives. Medicines are mostly used to reduce excitation and aggression, despite the limited evidence for efficacy in people with learning disability.

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Antipsychotic polypharmacy is strongly discouraged in widely-accepted international guidelines, including the NICE guidelines.1Polypharmacy may lead to an increased potential for adverse drug effects, unwanted pharmacokinetic drug interactions, and an increase in the cumulative antipsychotic dose increasing the risk of tardive dyskinesia.2,19

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Independent Variables. Potential predictors of psychotropic use and/or episodes of multiclass psychotropic polypharmacy were identified through a review of the literature and included gender, household income, race/ethnicity, geographic region, age at index date, whether a child had at least 1 medical claim for a psychiatrist visit during the study, and indicator variables for neurologic and ...
In addition to relapse prevention and psychiatric symptom relief, the benefits of antipsychotics and mood stabilisers might also include reductions in the rates of violent crime. The potential effects of these drugs on violence and crime should be taken into account when treatment options for patients with psychiatric disorders are being considered.

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It is, however, unclear expert consensus guidelines do not advocate antipsy- if antipsychotic polypharmacy is associated with specific chotic polypharmacy, some [4] suggest antipsychotic atypical antipsychotics more often than with others. polypharmacy as the last resort after having exhausted prior monotherapy alternatives.
Antipsychotic medications are effective in the treatment of psychotic disorders. Monotherapy (MT) with antipsychotics is consistently recommended as the treatment of choice by several guidelines yet antipsychotic polypharmacy (APP) is widespread in clinical practice. The objectives of this study were to evaluate the incidence of APP,

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Antipsychotic polypharmacy, Part 1: Therapeutic option or dirty little secret? J Clin Psychiatry 1999, 60:425-426. 2 Messer T, Tiltscher C, Schmauss M. Polypharmazie in der Behandlung der Schizophrenie. Fortschr Neurol Psychiat 2006, 74:377-391. 3 Clark RE, Bartels SJ, Mellmann T.A., Peacock WJ.
Antipsychotic Polypharmacy May Reduce Long-Term Rehospitalization Risk, Study Finds A combination of clozapine plus aripiprazole was associated with the lowest risk of psychiatric rehospitalization among patients with schizophrenia who were followed for up to 20 years in Finland, according to a study published Wednesday in JAMA Psychiatry .

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ADHD polypharmacy increased from 16.8% to 20.5%, whereas psychotropic polypharmacy increased from 26.0% to 40.7%. The most common ADHD combinations were stimulants and α-2 agonists (67.1%), whereas the most common concomitant psychotropic agents were selective serotonin reuptake inhibitors (14.4%) and second-generation antipsychotics (11.8%).
Aug 01, 2004 · Methods Antipsychotic prescription for a sample of 2399 patients with schizophrenia from six countries and territories was evaluated. Daily doses of antipsychotic medications were converted to standard chlorpromazine equivalents (CPZ). Results Antipsychotic polypharmacy was found in 45.7% (n = 1097) of the patients with wide intercountry ...

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Antipsychotic polypharmacy was defined as 2 or more antipsychotics, which could include any combination of oral and LAIA formulations. ANY POL included POL ± CZP and L + P ± CZP. ANY LAI included LAI, L + O, and L + P ± CZP.

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First, there are still a large number of patients with treatment-resistant schizophrenia (TRS), which has led to a growing trend to resort to AAP polypharmacy with few side effects. Most clinical treatment guidelines recommend clozapine monotherapy in TRS, but around one third of schizophrenic patients fail to respond to clozapine.
Abstract Background Antipsychotic polypharmacy is defined as the concomitant prescribing of more than 1 antipsychotic medication for an individual patient. Despite clinical guideline recommendations, long-acting injectable antipsychotics (LAIAs) are often used together with oral antipsychotics (OAPs) to treat a variety of psychiatric illnesses.

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Oct 03, 2019 · Another emerging theme in the research literature, albeit a somewhat heretical one, is the value of antipsychotic polypharmacy, added Dr. Weiser, professor and chairman of the department of psychiatry at Sackler Faculty of Medicine, Tel Aviv University.
Moreover, the renewing edition of Korean clinical practice guideline for schizophrenic patients may be needed to include the reasonable recommendations of clozapine for refractory individuals, and monopharmacy for those who are receiving antipsychotic polypharmacy, which has been suggested by Essock et al. .

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Antipsychotic polypharmacy in residential facilities in Italy: the gap between recommendations and real world practice. Lucio Ghio, Werner Natta, Simona Gotelli, Luigi Ferrannini 5. Antipsychotic polypharmacy and associated phenomena in patients with schizophrenia: Rational or irrational? KH Yong, Norman Sartorius, Kang Sim 6. Antipsychotic ...
May 15, 2020 · Initial treatment: low‐dose antipsychotics (eg perphenazine 4–12/day; olanzapine 2.5–10mg/day; risperidone –‐4mg/day) Increase the dose of antipsychotics in partial or no efficacy. Add SSRIs (or MAOI) in partial efficacy and when there are prominent affective symptoms.

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Generally, the use of two or more antipsychotic medications concurrently should be avoided except in cases of three failed trials of monotherapy, which included one failed trial of clozapine where...
The Joint Commission’s HBIPS core measure set, implemented on October 1, 2008, includes two measures addressing antipsychotic polypharmacy: 1) assessing a hospital’s overall rateo f antipsychotic polypharmacy at discharge; and 2) measuring the number of cases with documentation at discharge of clinically appropriate justifications for the prescription of antipsychotic polypharmacy.

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Mar 01, 2019 · *Leucht S et al., Antipsychotic drugs versus placebo for relapse prevention in schizophrenia: a systematic review and meta-analysis. Lancet. 2012 Jun 2;379(9831):2063-71. Least tolerable: Haloperidol- Max. EPS 23. Depot preparations available in India Grover S et al., Clinical Practice Guidelines for Management of Schizophrenia.
The antipsychotic used the most was clozapine (11 studies, 542 patients). Antipsychotic polypharmacy was found to be superior to monotherapy with regard to all-cause discontinuation (RR 0.65, 95% CI 0.54-0.78, p<0.00001). However, in light of the small number of trials included and the considerable inhomogeneity concerning study methodology ...

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A majority (74%) of patients were prescribed antipsychotic monotherapy, and 19% received antipsychotic polypharmacy. Of patients receiving antipsychotic polypharmacy, 65% began polypharmacy within 90 days of starting any antipsychotic treatment. There was a fourfold difference in polypharmacy across facilities.

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