Nov 07, 2008 · Much of the available literature on psychotropic polypharmacy has focused on antipsychotic polypharmacy. 8,9,11,12,17,21,26,40,41 Frequently, antipsychotic polypharmacy represents an attempt by the physician to achieve a greater or a faster therapeutic response. 11 Many patients in routine care settings continue to experience significant symptoms while following usual treatment regimens. 42 In other cases, antipsychotic polypharmacy may be the result of “getting stuck” in switching from ...
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Antipsychotic polypharmacy has increased over the years, and current evidence suggeststhat it may have some clinical beneﬁts, most likely by enabling individualized and tailored antipsychotic treatment regimens for better symptom con-trol [4, 5]. Consequently, combined treatment strategies are frequently applied for treatment-refractory symptoms, even
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Jan 16, 2017 · The full guideline states that many types of psychotropic medicines have been used to manage behaviour that challenges, including antipsychotics, antidepressants, mood stabilisers and sedatives. Medicines are mostly used to reduce excitation and aggression, despite the limited evidence for efficacy in people with learning disability.
Antipsychotic polypharmacy is strongly discouraged in widely-accepted international guidelines, including the NICE guidelines.1Polypharmacy may lead to an increased potential for adverse drug effects, unwanted pharmacokinetic drug interactions, and an increase in the cumulative antipsychotic dose increasing the risk of tardive dyskinesia.2,19
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In addition to relapse prevention and psychiatric symptom relief, the benefits of antipsychotics and mood stabilisers might also include reductions in the rates of violent crime. The potential effects of these drugs on violence and crime should be taken into account when treatment options for patients with psychiatric disorders are being considered.
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Antipsychotic medications are effective in the treatment of psychotic disorders. Monotherapy (MT) with antipsychotics is consistently recommended as the treatment of choice by several guidelines yet antipsychotic polypharmacy (APP) is widespread in clinical practice. The objectives of this study were to evaluate the incidence of APP,
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Antipsychotic Polypharmacy May Reduce Long-Term Rehospitalization Risk, Study Finds A combination of clozapine plus aripiprazole was associated with the lowest risk of psychiatric rehospitalization among patients with schizophrenia who were followed for up to 20 years in Finland, according to a study published Wednesday in JAMA Psychiatry .
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Aug 01, 2004 · Methods Antipsychotic prescription for a sample of 2399 patients with schizophrenia from six countries and territories was evaluated. Daily doses of antipsychotic medications were converted to standard chlorpromazine equivalents (CPZ). Results Antipsychotic polypharmacy was found in 45.7% (n = 1097) of the patients with wide intercountry ...
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Abstract Background Antipsychotic polypharmacy is defined as the concomitant prescribing of more than 1 antipsychotic medication for an individual patient. Despite clinical guideline recommendations, long-acting injectable antipsychotics (LAIAs) are often used together with oral antipsychotics (OAPs) to treat a variety of psychiatric illnesses.
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Moreover, the renewing edition of Korean clinical practice guideline for schizophrenic patients may be needed to include the reasonable recommendations of clozapine for refractory individuals, and monopharmacy for those who are receiving antipsychotic polypharmacy, which has been suggested by Essock et al. .
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May 15, 2020 · Initial treatment: low‐dose antipsychotics (eg perphenazine 4–12/day; olanzapine 2.5–10mg/day; risperidone –‐4mg/day) Increase the dose of antipsychotics in partial or no efficacy. Add SSRIs (or MAOI) in partial efficacy and when there are prominent affective symptoms.
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The Joint Commission’s HBIPS core measure set, implemented on October 1, 2008, includes two measures addressing antipsychotic polypharmacy: 1) assessing a hospital’s overall rateo f antipsychotic polypharmacy at discharge; and 2) measuring the number of cases with documentation at discharge of clinically appropriate justifications for the prescription of antipsychotic polypharmacy.
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The antipsychotic used the most was clozapine (11 studies, 542 patients). Antipsychotic polypharmacy was found to be superior to monotherapy with regard to all-cause discontinuation (RR 0.65, 95% CI 0.54-0.78, p<0.00001). However, in light of the small number of trials included and the considerable inhomogeneity concerning study methodology ...